讲师 肿瘤学博士
E-mail : wangshengchun@gdmu.edu.cn
主要从事肿瘤发病的分子机理研究。目前主持广东省自然科学基金和广东省医学科学技术研究基金各1项。以第一作者及并列第一作者发表SCI论文3篇。
1. 广东省自然科学基金项目，转录因子Hes1促EMT转化对鼻咽癌干细胞的调控作用及机制（2016A030310357），2016/06-2019/06，主持。
2. 广东省医学科学技术研究基金项目，Hes1/PTEN信号轴调控鼻咽癌EMT和侵袭转移的机制研究（A2015105），2015/07-2017/06，主持。
1．Wang SC, Lin XL, Wang HY, Qin YJ, Chen L, Li J, Jia JS, Shen HF, Yang S, Xie RY, Wei F, Gao F, Rong XX, Yang J, Zhao WT, Zhang TT, Shi JW, Yao KT, Luo WR, Sun Y, Xiao D. Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway. Oncotarget. 2015 Nov 3;6(34):36713-30. (第一作者)
2．Wang SC, Lin XL, Li J, Zhang TT, Wang HY, Shi JW, Yang S, Zhao WT, Xie RY, Wei F, Qin YJ, Chen L, Yang J, Yao KT, Xiao D. MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA. PLoS One. 2014 Jul 3;9(7):e101330. (第一作者)
3．Gao F*, Zhang Y*, Wang S*, Liu Y*, Zheng L, Yang J, Ye Y, Luo W, Xiao D. Hes1 is involved in the self-renewal and tumourigenicity of stem-like cancer cells in colon cancer. Sci Rep. 2014 Feb 4;4:3963. (*并列第一作者)
4．Lin XL, Zhao WT, Jia JS, Lin TY, Xiao GF, Wang SC, Lin X, Liu Y, Chen L, Qin YJ, Li J, Zhang TT, Hao WC, Chen BZ, Xie RY, Cheng YS, Xu K, Yao KT, Huang WH, Xiao D, Sun Y. Ectopic expression of Cripto-1 in transgenic mouse embryos causes hemorrhages, fatal cardiac defects and embryonic lethality, Scientific Reports, 2016, 6:34501.
5．Lin XL, Qin YJ, Jia JS, Lin TY, Lin X, Chen L, Zeng H, Han YJ, Wu LH, Huang S, Wang M, Huang SH, Xie RY, Liang LQ, Liu Y, Liu RY, Zhang TT, Li J, Wang SC, Sun PH, Huang WH, Yao KT, Xu K, Du T, Xiao D. MiR-155 enhances insulin sensitivity by coordinated regulation of multiple genes in mice, PLoS Genet, 2016, 12(10):e1006308.
6．Shi JW, Liu W, Zhang TT, Wang SC, Lin XL, Li J, Jia JS, Sheng HF, Yao ZF, Zhao WT, Zhao ZL, Xie RY, Yang S, Gao F, Fan QR, Gu WW, Yao KT, Xiao D. The enforced expression of c-Myc in pig fibroblasts triggers mesenchymal-epithelial transition (MET) via F-actin reorganization and RhoA/Rock pathway inactivation. Cell Cycle. 2013 Apr 1;12(7):1119-27.
7．Gao F, Zhao ZL, Zhao WT, Fan QR, Wang SC, Li J, Zhang YQ, Shi JW, Lin XL, Yang S, Xie RY, Liu W, Zhang TT, Sun YL, Xu K, Yao KT, Xiao D. miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells. Biochem Biophys Res Commun. 2013 Feb 15;431(3):610-6.
8．Li J, Yang S, Yan W, Yang J, Qin YJ, Lin XL, Xie RY, Wang SC, Jin W, Gao F, Shi JW, Zhao WT, Jia JS, Shen HF, Ke JR, Liu B, Zhao YQ, Huang WH, Yao KT, Li DJ, Xiao D. MicroRNA-19 triggers epithelial-mesenchymal transition of lung cancer cells accompanied by growth inhibition. Lab Invest. 2015 Sep;95(9):1056-70.
1．王胜纯，姚运红，熊晖，曾超，唐加步，孙艳芹。细胞病理学多元化教学模式初探，基础医学教育，2016年12月，第18卷第12期。